Total synthesis and natural substances

Total synthesis enables the preparation of compounds of interest. It most often targets biologically functional complex molecules, generally natural substances that are difficult to access in nature, and thus responds to strategic and methodological challenges. The total syntheses developed in the Chemistry Department naturally target complex molecules with high application potential in the pharmaceutical (anticancer, antibiotics), agronomic (herbicides, insecticides) or more fundamental chemobiology fields. They are associated with a variety of methodological developments, aimed at the rapid generation of complexity and diversity: bio-inspired strategies, pericyclic or cascade reactions, photochemistry, rearrangements, catalysis...

1. Total synthesis and applications in chemobiology

2. Biomimetic strategies in total synthesis

3. Synthesis and valorization of a herbicidal natural substance

4. Highly convergent approaches and cascade reactions in total synthesis

5. Examples of complex molecules addressed in total synthesis: cinereain, corymbiferanes, cytochalasins, Daphniphyllum alkaloids, hirsutellone , kingianines, latrunculine B, radulanine A, talaroketal A

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